Publications

LEO Pharma employees were authors or co-authors on the following publications.

2014

Non-adherence to topical treatments for actinic keratosis Read more

Imaging of Distribution of Topically Applied Drug Molecules in Mouse Skin by Combination of Time-of-Flight Secondary Ion Mass Spectrometry and Scanning Electron Microscopy Read more

Real-life effectiveness of once-daily calcipotriol and betamethasone dipropionate gel vs. ointment formulations in psoriasis vulgaris: 4- and 12-week interim results from the PRO-long study Read more

Efficacy and Safety of Ingenol Mebutate 0.015% Gel 3 Weeks After Cryosurgery of Actinic Keratosis: 11-Week Results Read more



2013

Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer Read more

The biological rationale for use of vitamin d analogs in combination with corticosteroids for the topical treatment of plaque psoriasis Read more

Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer Read more

14-step synthesis of (+)-ingenol from (+)-3-carene Read more

Use of a psoriasis plaque test in the development of a gel formulation of calcipotriol and betamethasone dipropionate for scalp psoriasis Read more

CATCH: a randomised clinical trial comparing long-term tinzaparin versus warfarin for treatment of acute venous thromboembolism in cancer patients Read more

Identifying individual psychosocial and adherence support needs in patients with psoriasis: a multinational two-stage qualitative and quantitative study Read more

Disease quantification in dermatology: in vivo near-infrared spectroscopy measures correlate strongly with the clinical assessment of psoriasis severity Read more

Long-term follow-up study of ingenol mebutate gel for the treatment of actinic keratoses Read more

Operationalization and application of “early warning signs” to screen nanomaterials for harmful properties Read more

Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies Read more

A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin Read more



2012

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 1 Read more

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2 Read more

In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids Read more

Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells Read more

Psoriasis drug discovery - methods for evaluation of potential drug candidates Read more

Effect of low molecular weight heparins (LMWHs) on antiphospholipid antibodies (aPL) – mediated inhibition of endometrial angiogenesis Read more

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation Read more

Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin Read more

Comparison of microRNA expression using different preservation methods of matched psoriatic skin samples Read more

Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice Read more

Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment? Read more

Translating clinical activity and gene expression signatures of etanercept and ciclosporin to the psoriasis xenograft SCID mouse model Read more

Ingenol mebutate gel for actinic keratosis Read more

Emerging nonanticoagulant role of low molecular weight heparins on extravillous trophoblast functions and on heparin binding-epidermal growth factor and cystein-rich angiogenic inducer 61 expression Read more

Semisynthesis of ingenol 3-angelate (PEP005): Efficient stereoconservative angeloylation of alcohols Read more

Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α2β1 receptor Read more

Comparison of the antipsoriatic effect and tolerability of calcipotriol-contaning products in the treatment of psoriasis vulgaris using a modified psoriasis plaque test Read more

Calcipotriol delivery into the skin with PEGylated liposomes Read more

Ingenol mebutate-induced cell death patterns in normal and cancer epithelial cells Read more



2011

JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis Read more

IL-25 in atopic dermatitis - a possible link between inflammation and skin barrier dysfunction? Read more

IL-23-mediated epidermal hyperplasia is dependent on IL-6 Read more

Drug design of GPCR ligands using physicogenetics and chemogenomics - principles and case studies Read more

In vitro penetration properties of solid nanoparticles in intact and barrier-impaired skin Read more

Protamine neutralisation of low molecular weight heparins and their oligosaccharide components Read more

Targeting of liposome-associated calcipotriol to the skin: effect of liposomal membrane fluidity and skin barrier integrity Read more

A sleeping beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues Read more

Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL) Read more

CD4+ T cell depletion changes the cytokine environment from a TH1/TH2 response to a TC17-like response in a murine model of atopic dermatitis Read more

Cost effectiveness of the two-compound formulation calcipotriol and betamethasone dipropionate gel in the treatment of scalp psoriasis in Scotland Read more

The effectiveness of two-compound formulation calcipotriol and betamethasone dipropionate gel in the treatment of moderately severe scalp psoriasis: a systematic review of direct and indirect evidence Read more

Heterogeneity in the treatment of moderately severe scalp psoriasis in Scotland: results of a survey of Scottish health professionals Read more

Mixed treatment comparison of a two-compound formulation (TCF) product containing calcipotriol and betamethasone dipropionate with other topical treatments in psoriasis vulgaris Read more

A psoriasis-specific model to support decision making: UK experience Read more

We use cookies on this website

The cookies help us gain a better understanding of how you use our website; display applications and functionalities, to optimise your website experience, to assign a unique identification number to you, and to help you remember your user ID and password when you return to the website. We also use cookies to generate statistical information.

By continuing to browse our website, you are agreeing to our use of cookies

If you want to know more about our cookie policy and how to avoid and delete cookies click here.